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First-in-human Phase I/Ib Study of the Oral Werner (WRN) Helicase Inhibitor HRO761 in Patients With Microsatellite Instability-high or Mismatch Repair Deficient Advanced Solid Tumors: Interim Safety and Efficacy Analysis From HRO761 Single Agent Dose Escalation
Michael B. Foote, Jian Li, David S. Tan, Aitana Calvo Ferrandiz, Rachel Galot, Tormod Kyrre Guren, Antoine Italiano, Chia-Chi Lin, Arjun Oberoi, Zev A. Wainberg, Jeffrey Yachnin, Timothy A. Yap, Ruben De Kanter, Noemi Di Nanni, Nancy Grande, Aude Izaac, Dragana Jankovic, Laurent Sansregret, Cheng Zhang, Giorgia Clementi, Ankur Nagaraja, Yasutoshi Kuboki
Mini Oral Presentation #925MO
Heidelberg Auditorium - Hall 6.2 | Friday, October 17, 2025 | 16:35-16:40 CEST (Mini Oral) | 16:50-16:55 (Discussion)
A First-in-Human Study of Oral IAG933 in Adult Patients With Advanced Mesothelioma and Other Solid Tumours
Elena Garralda, Marie Florescu, Joachim G Aerts, Tatsuya Yoshida, Sophie Postel-Vinay, Ibiayi Dagogo-Jack, Matthew G. Krebs, Martin Metzenmacher, Thomas John, Hedy Kindler, Mehmet Altan, Lorenz Bankel, Dale R. Shepard, Zev Wainberg, Matteo Duca, Vincent K. Lam, Katelyn Parhiala, Maria-Athina Altzerinakou, Jason Faris, Armando Santoro
Proferred Paper/Oral Presentation #919O
Hanover Auditorium - Hall 7.2c I Sunday, October 19, 2025 | 16:30 – 16:40 CEST (Proffered Paper/Oral Presentation) | 17:00 – 17:10 CEST (Discussion)